The mission of the core is to provide MUSC and other regional investigators with expertise, instrumentation, training, and services for a range of molecular technologies. The core currently offers Bioanalyzer service for qualitative analysis of eukaryotic total RNA and quantitative analysis of DNA libraries. Several instruments are available to users, including qPCR, PCR, NanoDrop, microplate reader, and Qubit fluorometers. Following certification of training, users are free to schedule their use at their convenience. The core also offers bioinformatic analysis in support of bulk RNA-seq data analysis and other miscellaneous applications (database mining, cloning design, etc.). For RNA-seq projects, the core can access raw data from providers, run data analysis pipelines, securely store the data until publication, and assist users with submission of project data to public archives.

Representative:
Dr. Jeremy “Jamie” Barth
Director

Website

The IRF provides state-of-the-art biomedical research instrumentation for use in the USC School of Medicine Columbia and USC main campus research environments. 

IRF Discount for SC INBRE PUIs. The IRF is pleased to offer a discount to researchers from SC INBRE’s PUIs and Outreach Institutions. This discount allows eligible external researchers to access all IRF equipment and services at internal pricing, ensuring greater affordability and support for their research needs. Questions? Contact Dr. Austin Worden (email). 

Representative:
Dr. Austin Worden
Director

Website

The Clemson University Institute for Human Genetics is housed in Self Regional Hall, a state-of-the-art research and educational facility located in Greenwood, South Carolina. Research in the center focuses on genomic, computational and comparative genetic approaches to gain insights in genetic and environmental risk factors for human diseases.

The Institute promotes a collaborative interdisciplinary environment that involves faculty in Self Regional Hall and affiliated Institute members from the Department of Biological Sciences, the Department of Genetics and Biochemistry, and the School for Mathematics and Statistics on the main Clemson University campus. The Institute for Human Genetics actively engages regional, national and international partnerships and provides excellent opportunities for graduate students and postdoctoral research.

Genomics Core
The Genomics Core provides cutting-edge, end-to-end support for modern genomics research, offering state-of-the-art infrastructure for high-throughput sequencing and molecular biology workflows. Our expert staff work closely with investigators from experimental design through sequencing, ensuring high-quality results across a broad range of applications, including whole-genome sequencing, RNA-seq, single-cell sequencing (10x Genomics, Parse, and Illumina), and more. Equipped with advanced platforms such as the Illumina NovaSeq X+, PacBio Revio, ONT PromethION P2 Integrated, and 10x Genomics Chromium iX, the Genomics Core is a collaborative partner ready to support the evolving needs of cutting-edge genomic research. In addition to full-service sequencing, we offer hands-on wet-lab training courses and educational seminars to empower users with practical experience.

Representative: Kaitlyn Williams, Director, Email, Website

Bioinformatics and Statistics Core
The Statistics and Bioinformatics Core provides comprehensive computational genomics and statistical analysis services spanning single-cell and bulk transcriptomics, genetic variant analysis, epigenetics, microbiome analysis, population genetics, and network-based modeling. We offer expertise in GWAS and TWAS, along with rigorous statistical consultation to support robust experimental design from project inception through interpretation. Our dedicated high-performance computing environment features both CPU and heterogeneous GPU architectures, including NVIDIA and AMD GPUs, paired with petabyte-scale, high-throughput storage to support data-intensive workflows. We emphasize reproducible, end-to-end pipelines that ensure scalability, transparency, and long-term usability of results.

Representative: Dr. Vijay Shankar, Director, Email, Website

SC TRIMH’s primary mission is to develop a new generation of NIH-funded investigators by providing the intellectual expertise needed for one-on-one and group mentoring opportunities to early-stage and/or new investigators, financial support for investigators to obtain preliminary data and research infrastructure, through dedicated scientific cores, necessary for investigators to be successful in competing for NIH research awards. The specific aims are to:

Expand the critical mass of funded investigators conducting musculoskeletal research

Strengthen innovative scientific cores that support and advance musculoskeletal research

Advance the ongoing development of an independent, sustainable, multidisciplinary thematic program. 

Representative:
Thomas Gallien
Program Manager
Email

Website