Featured Faculty: Drew Budner

Drew BudnerDrew Budner, PhD,
 Coastal Carolina University

PROJECT TITLE:  Development of Prussian Blue Modified Biosensors

In an effort to improve and expand the availability of electrochemical sensors for biologically important molecules such as glucose, an investigation into the coupling of Prussian Blue nanomaterials with xerogels containing enzymes is proposed. Prussian Blue has been shown to reduce hydrogen peroxide at low potential (approximately 0 V vs Ag/AgCl). In order to improve the stability of these Prussian Blue modified electrodes the nanostructuring by deposition through microporous screens and stabilization by filling the voids with nickel hexacyanoferrate will be performed. To make these modified electrodes they will be covered with xerogels that have incorporated glucoses oxidase into the gel pours. The byproduct of the interaction of glucose and the enzyme is hydrogen peroxide which will be reduced at the electrode surface by the Prussian Blue. In a complementary study, Prussian Blue nanoparticles will be incorporated within the xerogel matrix with the enzyme. This would allow reaction of the glucose to form hydrogen peroxide which is subsequently reduced will happen in close proximity reducing response time and increase sensitivity.

The work on this project would not have been possible with funding from NIGMS/SC INBRE. The support from SC INBRE provided funding for two undergraduate research students and one secondary research student.

The initial investigations into the improvement of sensor stability based on incorporation of polyanaline and nickel hexacyanoferrate was undertaken. In addition, a method of ordered deposition through an inert membrane to improve sensor performance was initiated. Plus, initial investigation of incorporation of Prussian Blue within a deposited xerogel was started.

November 10, 2017

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SC INBRE is funded by grant P20GM103499 from the National Institute of General Medical Sciences, National Institutes of Health