FURMAN: Hollis et. al. to be published in Journal of Chemical Neuroanatomy

Dr. David Hollis, associate professor in the Department of Biology at Furman University, along with two students recently received acceptance for a publication: 

Downs AG, Scholles KR, and Hollis DM. 2016Localization of rem2 in the central nervous system of the adult rainbow trout (Oncorhynchus mykiss). Journal of Chemical Neuroanatomy. 78: 87-95.

This publication is a result of Hollis' last “Target Faculty” NIH-INBRE funded work from 5 P20 RR-016461 and 8 P20 GM103499. Two INBRE-supported undergraduates, Anna Downs and Katie Scholles, were co-authors on this publication – one was directly stipend supported by INBRE and both received supplies via INBRE. 

"A really great aspect of this paper is that establishing and optimizing the protocol for the major method used (in situ hybridization) takes a lot of effort, which I could only accomplish via time  - afforded by sabbatical – and of course, funding. Had it not been for INBRE, there was no way to pull off establishing the technique as a standard protocol in my lab and accumulate enough manuscript worthy data.” said Hollis. 

The Hollis lab is interested in the molecular mechanisms that give adult anamniotic vertebrates (fish and amphibians) their tremendous brain regenerative capacity. One such molecule of interest is the protein Rem2. Rem2 is a unique small molecule GTPase distinguished by its extremely high levels in the brain relative to all other tissues and is known to influence cell proliferation. In this paper, the lab looked for where rem2 is expressed in the fish (trout) brain because, as adults, fish have massive brain cell proliferative capabilities compared to mammals. Thus, they determined where the sphere of influence for Rem2 occurs in the brain of a regenerative-capable adult vertebrate. 

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Article Pubished: September 16, 2016

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SC INBRE is funded by grant P20GM103499 from the National Institute of General Medical Sciences, National Institutes of Health

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